1WBG

Active site thrombin inhibitors

Summary for 1WBG
Related1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX 1BMM 1BMN 1BTH 1C1U 1C1V 1C1W 1C4U 1C4V 1C4Y 1C5L 1C5N 1C5O 1CA8 1D3D 1D3P 1D3Q 1D3T 1D4P 1D6W 1D9I 1DE7 1DIT 1DM4 1DOJ 1DWB 1DWC 1DWD 1DWE 1DX5 1E0F 1EB1 1EOJ 1EOL 1FPC 1FPH 1G30 1G32 1G37 1GHV 1GHW 1GHX 1GHY 1GJ4 1GJ5 1H8D 1H8I 1HAG 1HAH 1HAI 1HAO 1HAP 1HBT 1HDT 1HGT 1HLT 1HUT 1HXE 1HXF 1IHS 1IHT 1JMO 1JOU 1JWT 1K21 1K22 1KTS 1KTT 1LHC 1LHD 1LHE 1LHF 1LHG 1MH0 1MU6 1MU8 1MUE 1NM6 1NO9 1NRN 1NRO 1NRP 1NRQ 1NRR 1NRS 1NT1 1NU7 1NU9 1NY2 1NZQ 1O0D 1O2G 1O5G 1OOK 1OYT 1P8V 1PPB 1QBV 1QHR 1QJ1 1QJ6 1QJ7 1QUR 1QVH 1RD3 1RIW 1SB1 1SFQ 1SG8 1SGI 1SHH 1SL3 1SR5 1TA2 1TA6 1TB6 1TBZ 1THP 1THR 1THS 1TMB 1TMT 1TMU 1TOM 1TQ0 1TQ7 1UMA 1UVS 1VR1 1VZQ 1W7G 1WAY 1WBG 2HGT 2HNT 2HPP 2HPQ 2THF 3HAT 3HTC 4HTC 4THN 5GDS 7KME 8KME
DescriptorTHROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUGEN, ... (6 entities in total)
Functional Keywordsblood coagulation-inhibitor, serine protease, blood coagulation, acute phase, calcium-binding, disease mutation, gamma-carboxyglutamic acid, glycoprotein, kringle, polymorphisme, vitamin k, zymogen, sulfation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
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Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P09945
Total number of polymer chains3
Total formula weight35700.25
Authors
Hartshorn, M.J.,Murray, C.W.,Cleasby, A.,Frederickson, M.,Tickle, I.J.,Jhoti, H. (deposition date: 2004-11-01, release date: 2005-01-27, Last modification date: 2017-06-28)
Primary citationCleasby, A.,Frederickson, M.,Hartshorn, M.J.,Jhoti, H.,Murray, C.W.,Tickle, I.J.
Fragment-Based Lead Discovery Using X-Ray Crystallography
J.Med.Chem., 48:403-, 2005
PubMed: 15658854
DOI: 110.1021/JM0495778
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation
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PDB entries from 2021-06-23