1DOJ

Crystal structure of human alpha-thrombin*RWJ-51438 complex at 1.7 A

Summary for 1DOJ

• Entry DOI: 10.2210/pdb1doj/pdb
• Related: 1abj
• Related PRD ID: PRD_000623
• Descriptor: ALPHA-THROMBIN, HIRUGEN, N-methyl-D-phenylalanyl-N-{(1S)-4-carbamimidamido-1-[(6-carboxy-1,3-benzothiazol-2-yl)carbonyl]butyl}-L-prolinamide, ... (6 entities in total)
• Functional Keywords: thrombin, serine protease, enzyme inhibition, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 36211.14

Authors

Recacha, R.,Costanzo, M.J.,Maryanoff, B.E.,Carson, M.,DeLucas, L.,Chattopadhyay, D. (deposition date: 1999-12-21, release date: 2000-11-03, Last modification date: 2024-03-13)

• Primary citation: Recacha, R.,Costanzo, M.J.,Maryanoff, B.E.,Carson, M.,DeLucas, L.,Chattopadhyay, D.; Structure of human alpha-thrombin complexed with RWJ-51438 at 1.7 A: unusual perturbation of the 60A-60I insertion loop.; Acta Crystallogr.,Sect.D, 56:1395-1400, 2000; PubMed: 11053836; DOI: 10.1107/S0907444900010763

Experimental method

X-RAY DIFFRACTION (1.7 Å)