1C4U

SELECTIVE NON ELECTROPHILIC THROMBIN INHIBITORS WITH CYCLOHEXYL MOIETIES.

Summary for 1C4U

• Entry DOI: 10.2210/pdb1c4u/pdb
• Descriptor: thrombin, PROTEIN (HIRUGEN), SODIUM ION, ... (6 entities in total)
• Functional Keywords: complex (serine protease-inhibitor), hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• Total number of polymer chains: 3
• Total formula weight: 36133.89

Authors

Krishnan, R.,Mochalkin, I.,Arni, R.K.,Tulinsky, A. (deposition date: 1999-09-25, release date: 2000-09-27, Last modification date: 2023-11-15)

• Primary citation: Krishnan, R.,Mochalkin, I.,Arni, R.,Tulinsky, A.; Structure of thrombin complexed with selective non-electrophilic inhibitors having cyclohexyl moieties at P1.; Acta Crystallogr.,Sect.D, 56:294-303, 2000; PubMed: 10713516; DOI: 10.1107/S0907444900000068

Experimental method

X-RAY DIFFRACTION (2.1 Å)