2A45

Crystal structure of the complex between thrombin and the central "E" region of fibrin

Replaces:  1QVH

Summary for 2A45

• Entry DOI: 10.2210/pdb2a45/pdb
• Related PRD ID: PRD_000020
• Descriptor: Thrombin light chain, Thrombin heavy chain, Fibrinogen alpha chain, ... (7 entities in total)
• Functional Keywords: thrombin, fibrin, fragment e, thrombin-fibrin complex, coiled coils, disulfide rings, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 10
• Total formula weight: 111917.71

Authors

Pechik, I.,Madrazo, J.,Gilliland, G.L.,Medved, L. (deposition date: 2005-06-27, release date: 2006-05-02, Last modification date: 2023-08-23)

• Primary citation: Pechik, I.,Yakovlev, S.,Mosesson, M.W.,Gilliland, G.L.,Medved, L.; Structural basis for sequential cleavage of fibrinopeptides upon fibrin assembly.; Biochemistry, 45:3588-3597, 2006; PubMed: 16533041; DOI: 10.1021/bi0525369

Experimental method

X-RAY DIFFRACTION (3.65 Å)