2A45

Crystal structure of the complex between thrombin and the central "E" region of fibrin

Replaces:  1QVH

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D	Thrombin light chain	polymer	36	4096.5	2	UniProt (P00734) Pfam (PF09396) In PDB	Homo sapiens (human)	Coagulation factor II
2	B, E	Thrombin heavy chain	polymer	259	29780.2	2	UniProt (P00734) Pfam (PF00089) In PDB	Homo sapiens (human)	Coagulation factor II
3	G, J	Fibrinogen alpha chain	polymer	57	6642.4	2	UniProt (P02671) Pfam (PF08702) In PDB	Homo sapiens (human)
4	H, K	Fibrinogen beta chain	polymer	91	9787.1	2	UniProt (P02675) Pfam (PF08702) In PDB	Homo sapiens (human)
5	I, L	Fibrinogen gamma chain	polymer	45	5103.7	2	UniProt (P02679) In PDB	Homo sapiens (human)
6	B, E	D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide	non-polymer		454.0	2	BIRD (PRD_000020) Chemie (0G6)		PRO2061
7	B, E	PHOSPHATE ION	non-polymer		95.0	2	Chemie (PO4)

Contents of the asymmetric unit

Polymers	Number of chains	10
	Total formula weight	110819.8
Non-Polymers*	Number of molecules	4
	Total formula weight	1097.9
All*	Total formula weight	111917.7

*Water molecules are not included.