1QJ6
Novel Covalent Active Site Thrombin Inhibitors
Summary for 1QJ6
Entry DOI | 10.2210/pdb1qj6/pdb |
Related | 1QJ1 1QJ7 |
Descriptor | THROMBIN, HIRUGEN, 6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID, ... (5 entities in total) |
Functional Keywords | hydrolase-hydrolase inhibitor complex, blood coagulation-inhibitor complex, proteinase, blood coagulation, trypsin like proteinase, protease-inhibitor complex, hydrolase- hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35636.63 |
Authors | Jhoti, H.,Cleasby, A. (deposition date: 1999-06-22, release date: 2000-06-22, Last modification date: 2018-05-30) |
Primary citation | Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.,Weir, M.,Wonacott, A. Crystal Structures of Thrombin Complexed to a Novel Series of Synthetic Inhibitors Containing a 5,5-Trans-Lactone Template Biochemistry, 38:7969-, 1999 Cited by PubMed: 10387040DOI: 10.1021/BI9830359 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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