2THF

STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE

Summary for 2THF

Entry DOI	10.2210/pdb2thf/pdb
Related PRD ID	PRD_000020
Descriptor	THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (5 entities in total)
Functional Keywords	serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734
Total number of polymer chains	2
Total formula weight	34337.73
Authors	Caccia, S.,Futterer, K.,Di Cera, E.,Waksman, G. (deposition date: 1999-01-26, release date: 1999-03-07, Last modification date: 2023-08-30)
Primary citation	Guinto, E.R.,Caccia, S.,Rose, T.,Futterer, K.,Waksman, G.,Di Cera, E. Unexpected crucial role of residue 225 in serine proteases. Proc.Natl.Acad.Sci.USA, 96:1852-1857, 1999 Cited by PubMed: 10051558 DOI: 10.1073/pnas.96.5.1852 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation