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1A3B

COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1

Summary for 1A3B
Entry DOI10.2210/pdb1a3b/pdb
DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ... (5 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28504
Total number of polymer chains3
Total formula weight36405.20
Authors
Skordalakes, E.,Elgendy, S.,Dodson, G.,Goodwin, C.A.,Green, D.,Scully, M.F.,Freyssinet, J.H.,Kakkar, V.V.,Deadman, J. (deposition date: 1998-01-20, release date: 1998-06-03, Last modification date: 2011-07-13)
Primary citationSkordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scully, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J.J.
Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37:14420-14427, 1998
Cited by
PubMed: 9772168
DOI: 10.1021/bi980225a
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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