1A3B
COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1
Summary for 1A3B
Entry DOI | 10.2210/pdb1a3b/pdb |
Descriptor | ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ... (5 entities in total) |
Functional Keywords | complex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28504 |
Total number of polymer chains | 3 |
Total formula weight | 36405.20 |
Authors | Skordalakes, E.,Elgendy, S.,Dodson, G.,Goodwin, C.A.,Green, D.,Scully, M.F.,Freyssinet, J.H.,Kakkar, V.V.,Deadman, J. (deposition date: 1998-01-20, release date: 1998-06-03, Last modification date: 2011-07-13) |
Primary citation | Skordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scully, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J.J. Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide. Biochemistry, 37:14420-14427, 1998 Cited by PubMed: 9772168DOI: 10.1021/bi980225a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
Download full validation report