1A3B

COMPLEX OF HUMAN ALPHA-THROMBIN WITH THE BIFUNCTIONAL BORONATE INHIBITOR BOROLOG1

Summary for 1A3B

DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), Hirudin, ... (5 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space P00734 P00734
Secreted P28504
Total number of polymer chains3
Total molecular weight36405.2
Authors
Skordalakes, E.,Elgendy, S.,Dodson, G.,Goodwin, C.A.,Green, D.,Scully, M.F.,Freyssinet, J.H.,Kakkar, V.V.,Deadman, J. (deposition date: 1998-01-20, release date: 1998-06-03, Last modification date: 2011-07-13)
Primary citation
Skordalakes, E.,Elgendy, S.,Goodwin, C.A.,Green, D.,Scully, M.F.,Kakkar, V.V.,Freyssinet, J.M.,Dodson, G.,Deadman, J.J.
Bifunctional peptide boronate inhibitors of thrombin: crystallographic analysis of inhibition enhanced by linkage to an exosite 1 binding peptide.
Biochemistry, 37:14420-14427, 1998
PubMed: 9772168 (PDB entries with the same primary citation)
DOI: 10.1021/bi980225a
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.8 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers1004.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution