1TQ0
Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form
Summary for 1TQ0
Entry DOI | 10.2210/pdb1tq0/pdb |
Descriptor | Prothrombin (3 entities in total) |
Functional Keywords | thrombin, anticoagulant, blood clotting |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 4 |
Total formula weight | 66135.93 |
Authors | Pineda, A.O.,Chen, Z.-W.,Caccia, S.,Savvides, S.N.,Waksman, G.,Mathews, F.S.,Di Cera, E. (deposition date: 2004-06-16, release date: 2004-08-03, Last modification date: 2023-08-23) |
Primary citation | Pineda, A.O.,Chen, Z.-W.,Caccia, S.,Cantwell, A.M.,Savvides, S.N.,Waksman, G.,Mathews, F.S.,Di Cera, E. The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket J.Biol.Chem., 279:39824-39828, 2004 Cited by PubMed: 15252033DOI: 10.1074/jbc.M407272200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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