1TQ0
Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Prothrombin | polymer | 31 | 3647.1 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B, D (B, D) | Prothrombin | polymer | 257 | 29420.9 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | E, F, G, H (A, B, C, D) | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 245 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 215 | Trp 590 | engineered mutation |
| Ala 217 | Glu 592 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66135.9 | |
| All* | Total formula weight | 66135.9 |
