1TQ0
Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Prothrombin | polymer | 31 | 3647.1 | 2 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (human) | Coagulation factor II |
2 | B, D | Prothrombin | polymer | 257 | 29420.9 | 2 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (human) | |
3 | water | water | 18.0 | 176 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 245 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Ala 215 | Trp 590 | engineered mutation |
Ala 217 | Glu 592 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 66135.9 | |
All* | Total formula weight | 66135.9 |