1TQ0

Crystal structure of the potent anticoagulant thrombin mutant W215A/E217A in free form

Summary for 1TQ0

• Entry DOI: 10.2210/pdb1tq0/pdb
• Descriptor: Prothrombin (3 entities in total)
• Functional Keywords: thrombin, anticoagulant, blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 4
• Total formula weight: 66135.93

Authors

Pineda, A.O.,Chen, Z.-W.,Caccia, S.,Savvides, S.N.,Waksman, G.,Mathews, F.S.,Di Cera, E. (deposition date: 2004-06-16, release date: 2004-08-03, Last modification date: 2023-08-23)

• Primary citation: Pineda, A.O.,Chen, Z.-W.,Caccia, S.,Cantwell, A.M.,Savvides, S.N.,Waksman, G.,Mathews, F.S.,Di Cera, E.; The anticoagulant thrombin mutant W215A/E217A has a collapsed primary specificity pocket; J.Biol.Chem., 279:39824-39828, 2004; PubMed: 15252033; DOI: 10.1074/jbc.M407272200

Experimental method

X-RAY DIFFRACTION (2.8 Å)