1QHR
NOVEL COVALENT ACTIVE SITE THROMBIN INHIBITORS
Summary for 1QHR
Entry DOI | 10.2210/pdb1qhr/pdb |
Descriptor | ALPHA THROMBIN, HIRUGEN, 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE, ... (5 entities in total) |
Functional Keywords | proteinase, blood coagulation, trypsin like proteinase, complex (serine protease-inhibitor), blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35466.47 |
Authors | Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.,Wonacott, A. (deposition date: 1999-05-26, release date: 2000-05-31, Last modification date: 2023-12-27) |
Primary citation | Jhoti, H.,Cleasby, A.,Reid, S.,Thomas, P.J.,Weir, M.,Wonacott, A. Crystal structures of thrombin complexed to a novel series of synthetic inhibitors containing a 5,5-trans-lactone template. Biochemistry, 38:7969-7977, 1999 Cited by PubMed: 10387040DOI: 10.1021/bi9830359 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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