1DWC

CRYSTALLOGRAPHIC ANALYSIS AT 3.0-ANGSTROMS RESOLUTION OF THE BINDING TO HUMAN THROMBIN OF FOUR ACTIVE SITE-DIRECTED INHIBITORS

Summary for 1DWC

• Entry DOI: 10.2210/pdb1dwc/pdb
• Related: 1DWB 1DWD 1DWE
• Related PRD ID: PRD_000452
• Descriptor: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUDIN IIIA, ... (5 entities in total)
• Functional Keywords: serine proteinase, hydrolase-hyrolase inhibitor complex, hydrolase/hyrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28508
• Total number of polymer chains: 3
• Total formula weight: 35797.86

Authors

Banner, D.W.,Hadvary, P. (deposition date: 1992-08-19, release date: 1994-01-31, Last modification date: 2012-12-12)

• Primary citation: Banner, D.W.,Hadvary, P.; Crystallographic analysis at 3.0-A resolution of the binding to human thrombin of four active site-directed inhibitors.; J.Biol.Chem., 266:20085-20093, 1991; PubMed: 1939071

Experimental method

X-RAY DIFFRACTION (3 Å)