1AI8

HUMAN ALPHA-THROMBIN TERNARY COMPLEX WITH THE EXOSITE INHIBITOR HIRUGEN AND ACTIVE SITE INHIBITOR PHCH2OCO-D-DPA-PRO-BOROMPG

Summary for 1AI8

• Entry DOI: 10.2210/pdb1ai8/pdb
• Descriptor: ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUDIN IIIB, ... (5 entities in total)
• Functional Keywords: serine proteinase, blood coagulation, hydrolase-hydrolase inhibitor complex, blood coagulation-hydrolase inhibitor complex, blood coagulation/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 36061.83

Authors

Skordalakes, E.,Dodson, G.,Elgendy, S.,Goodwin, C.A.,Green, D.,Tyrrel, R.,Scully, M.F.,Freyssinet, J.,Kakkar, V.V.,Deadman, J. (deposition date: 1997-05-01, release date: 1997-10-15, Last modification date: 2023-08-02)

• Primary citation: Bode, W.,Turk, D.,Karshikov, A.; The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.; Protein Sci., 1:426-471, 1992; PubMed: 1304349

Experimental method

X-RAY DIFFRACTION (1.85 Å)