1SB1
Novel Non-Covalent Thrombin Inhibitors Incorporating P1 4,5,6,7-Tetrahydrobenzothiazole Arginine Side Chain Mimetics
Summary for 1SB1
Entry DOI | 10.2210/pdb1sb1/pdb |
Descriptor | Prothrombin, hirugen, SODIUM ION, ... (6 entities in total) |
Functional Keywords | thrombin, inhibition, hirugen, serine protease inhibitor, blood clotting, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28504 |
Total number of polymer chains | 3 |
Total formula weight | 34949.89 |
Authors | Marinko, P.,Krbavcic, A.,Mlinsek, G.,Solmajer, T.,Trampus-Bakija, A.,Stegnar, M.,Stojan, J.,Kikelj, D. (deposition date: 2004-02-09, release date: 2004-06-08, Last modification date: 2011-11-16) |
Primary citation | Marinko, P.,Krbavcic, A.,Mlinsek, G.,Solmajer, T.,Trampus-Bakija, A.,Stegnar, M.,Stojan, J.,Kikelj, D. Novel non-covalent thrombin inhibitors incorporating P(1) 4,5,6,7-tetrahydrobenzothiazole arginine side chain mimetics Eur.J.Med.Chem., 39:257-265, 2004 Cited by PubMed: 15051174DOI: 10.1016/j.ejmech.2003.12.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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