1TMB
MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A
Summary for 1TMB
Entry DOI | 10.2210/pdb1tmb/pdb |
Related PRD ID | PRD_000428 |
Descriptor | ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (5 entities in total) |
Functional Keywords | serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P09945 |
Total number of polymer chains | 4 |
Total formula weight | 36260.23 |
Authors | Qiu, X.,Padmanabhan, K.P.,Maryanoff, B.E.,Tulinsky, A. (deposition date: 1993-05-27, release date: 1994-01-31, Last modification date: 2023-11-15) |
Primary citation | Maryanoff, B.E.,Qiu, X.,Padmanabhan, K.P.,Tulinsky, A.,Almond Jr., H.R.,Andrade-Gordon, P.,Greco, M.N.,Kauffman, J.A.,Nicolaou, K.C.,Liu, A. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc.Natl.Acad.Sci.USA, 90:8048-8052, 1993 Cited by PubMed: 8367461DOI: 10.1073/pnas.90.17.8048 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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