1TMB

MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A

Summary for 1TMB

Entry DOI	10.2210/pdb1tmb/pdb
Related PRD ID	PRD_000428
Descriptor	ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (5 entities in total)
Functional Keywords	serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P09945
Total number of polymer chains	4
Total formula weight	36260.23
Authors	Qiu, X.,Padmanabhan, K.P.,Maryanoff, B.E.,Tulinsky, A. (deposition date: 1993-05-27, release date: 1994-01-31, Last modification date: 2023-11-15)
Primary citation	Maryanoff, B.E.,Qiu, X.,Padmanabhan, K.P.,Tulinsky, A.,Almond Jr., H.R.,Andrade-Gordon, P.,Greco, M.N.,Kauffman, J.A.,Nicolaou, K.C.,Liu, A. Molecular basis for the inhibition of human alpha-thrombin by the macrocyclic peptide cyclotheonamide A. Proc.Natl.Acad.Sci.USA, 90:8048-8052, 1993 Cited by PubMed: 8367461 DOI: 10.1073/pnas.90.17.8048 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation