1TMB
MOLECULAR BASIS FOR THE INHIBITION OF HUMAN ALPHA-THROMBIN BY THE MACROCYCLIC PEPTIDE CYCLOTHEONAMIDE A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | ALPHA-THROMBIN (SMALL SUBUNIT) | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | |
| 2 | B (H) | ALPHA-THROMBIN (LARGE SUBUNIT) | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | |
| 3 | C (I) | HIRUGEN | polymer | 13 | 1632.7 | 1 | UniProt (P09945) | ||
| 4 | D (T) | cyclotheonamide A | polymer | 5 | 750.8 | 1 | NOR (NOR00471) BIRD (PRD_000428) | Theonella sp. (sponges) | |
| 5 | E, F, G, H (L, H, I, T) | water | water | 18.0 | 239 | Chemie (HOH) |
Sequence modifications
I: 53 - 64 (UniProt: P09945)
| PDB | External Database | Details |
|---|---|---|
| Glu 54 | Gly 61 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 36260.2 | |
| All* | Total formula weight | 36260.2 |
