1BMN
HUMAN ALPHA-THROMBIN COMPLEXED WITH [S-(R*,R*)]-1-(AMINOIMINOMETHYL)-N-[[1-[N-[(2-NAPHTHALENYLSULFONYL)-L-SERYL]-PYRROLIDINYL]METHYL]-3-PIPERIDENECARBOXAMIDE (BMS-189090)
Summary for 1BMN
Entry DOI | 10.2210/pdb1bmn/pdb |
Descriptor | ALPHA-THROMBIN, HIRUDIN I, [S-(R*,R*)]-1-(AMINOIMINOMETHYL)-N-[[1-[N-[(2-NAPHTHALENYLSULFONYL)-L-SERYL]-3-PYRROLIDINYL]METHYL]-3-PIPERIDENECARBOXAMIDE, ... (5 entities in total) |
Functional Keywords | hydrolase, complex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28507 |
Total number of polymer chains | 3 |
Total formula weight | 35875.91 |
Authors | Malley, M.,Sack, J. (deposition date: 1995-11-14, release date: 1996-12-07, Last modification date: 2011-07-13) |
Primary citation | Malley, M.F.,Tabernero, L.,Chang, C.Y.,Ohringer, S.L.,Roberts, D.G.,Das, J.,Sack, J.S. Crystallographic determination of the structures of human alpha-thrombin complexed with BMS-186282 and BMS-189090. Protein Sci., 5:221-228, 1996 Cited by PubMed: 8745399PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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