1THP

STRUCTURE OF HUMAN ALPHA-THROMBIN Y225P MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE

Summary for 1THP

Entry DOI	10.2210/pdb1thp/pdb
Related PRD ID	PRD_000020
Descriptor	PROTEIN (THROMBIN LIGHT CHAIN), PROTEIN (THROMBIN HEAVY CHAIN), D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (4 entities in total)
Functional Keywords	serine protease, fprck, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734
Total number of polymer chains	2
Total formula weight	34264.68
Authors	Caccia, S.,Futterer, K.,Di Cera, E.,Waksman, G. (deposition date: 1999-01-26, release date: 1999-03-03, Last modification date: 2023-08-23)
Primary citation	Guinto, E.R.,Caccia, S.,Rose, T.,Futterer, K.,Waksman, G.,Di Cera, E. Unexpected crucial role of residue 225 in serine proteases. Proc.Natl.Acad.Sci.USA, 96:1852-1857, 1999 Cited by PubMed: 10051558 DOI: 10.1073/pnas.96.5.1852 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation