1THP
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225P MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PROTEIN (THROMBIN LIGHT CHAIN) | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) In PDB | Homo sapiens (human) | |
2 | B | PROTEIN (THROMBIN HEAVY CHAIN) | polymer | 259 | 29714.2 | 1 | UniProt (P00734) Pfam (PF00089) In PDB | Homo sapiens (human) | |
3 | B | D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide | non-polymer | 454.0 | 1 | BIRD (PRD_000020) Chemie (0G6) | |||
4 | water | water | 18.0 | 169 | Chemie (HOH) |
Sequence modifications
B: 16 - 245 (UniProt: P00734)
PDB | External Database | Details |
---|---|---|
Pro 225 | Tyr 225 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 33810.7 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 454.0 | |
All* | Total formula weight | 34264.7 |