1O0D
Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor
Summary for 1O0D
Entry DOI | 10.2210/pdb1o0d/pdb |
Related | 1A5G 1NZQ 1PPB |
Related PRD ID | PRD_000480 |
Descriptor | Thrombin light chain, Thrombin heavy chain, Decapeptide Hirudin Analogue, ... (5 entities in total) |
Functional Keywords | ternary complex; thrombin-active-site inhibitor-exo-site inhibitor, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35847.90 |
Authors | Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2003-02-21, release date: 2003-10-14, Last modification date: 2018-04-04) |
Primary citation | Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety Bioorg.Med.Chem.Lett., 13:2029-2033, 2003 Cited by PubMed: 12781189DOI: 10.1016/S0960-894X(03)00236-1 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
Download full validation report