1O0D

Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor

Summary for 1O0D

• Entry DOI: 10.2210/pdb1o0d/pdb
• Related: 1A5G 1NZQ 1PPB
• Related PRD ID: PRD_000480
• Descriptor: Thrombin light chain, Thrombin heavy chain, Decapeptide Hirudin Analogue, ... (5 entities in total)
• Functional Keywords: ternary complex; thrombin-active-site inhibitor-exo-site inhibitor, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 3
• Total formula weight: 35847.90

Authors

Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W. (deposition date: 2003-02-21, release date: 2003-10-14, Last modification date: 2018-04-04)

Primary citation

Lange, U.E.,Bauke, D.,Hornberger, W.,Mack, H.,Seitz, W.,Hoeffken, H.W.
D-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety
Bioorg.Med.Chem.Lett., 13:2029-2033, 2003

PubMed Abstract: Synthesis of thrombin inhibitors and their binding mode to thrombin is described. Modification of the P1 moiety leads to an increased selectivity versus trypsin. The observed selectivity is discussed in view of their thrombin-inhibitor complex X-ray structures.

PubMed: 12781189
DOI: 10.1016/S0960-894X(03)00236-1

Experimental method

X-RAY DIFFRACTION (2.44 Å)