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1O0D

Human Thrombin complexed with a d-Phe-Pro-Arg-type Inhibitor and a C-terminal Hirudin derived exo-site inhibitor

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(L)
Thrombin light chainpolymer364096.51UniProt (P00734)
Pfam (PF09396)
Homo sapiens (human)Coagulation factor II
2B
(H)
Thrombin heavy chainpolymer25929780.21UniProt (P00734)
Pfam (PF00089)
Homo sapiens (human)Coagulation factor II
3C
(D)
Decapeptide Hirudin Analoguepolymer111514.61BIRD (PRD_000480)Hirudo medicinalis
4D
(H)
(2-{2-[(5-CARBAMIMIDOYL-1-METHYL-1H-PYRROL-2-YLMETHYL)-CARBAMOYL]-PYRROL-1-YL}- 1-CYCLOHEXYLMETHYL-2-OXO-ETHYLAMINO)-ACETIC ACIDnon-polymer456.51Chemie (163)
5E, F, G
(L, H, D)
waterwater18.0174Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight35391.4
Non-Polymers*Number of molecules1
Total formula weight456.5
All*Total formula weight35847.9
*Water molecules are not included.

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PDB entries from 2025-07-30

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