1A5G

HUMAN THROMBIN COMPLEXED WITH NOVEL SYNTHETIC PEPTIDE MIMETIC INHIBITOR AND HIRUGEN

Summary for 1A5G

Related PRD IDPRD_000618
DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), HIRUGEN, ... (6 entities in total)
Functional Keywordscomplex (serine protease-inhibitor), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space P00734 P09945
Secreted P00734
Total number of polymer chains3
Total molecular weight36035.99
Authors
St Charles, R.,Tulinsky, A.,Kahn, M. (deposition date: 1998-02-16, release date: 1998-05-27, Last modification date: 2012-12-12)
Primary citation
St Charles, R.,Matthews, J.H.,Zhang, E.,Tulinsky, A.
Bound structures of novel P3-P1' beta-strand mimetic inhibitors of thrombin.
J.Med.Chem., 42:1376-1383, 1999
PubMed: 10212123 (PDB entries with the same primary citation)
DOI: 10.1021/jm980052n
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.06 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers27 2.2% 8.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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171313
PDB entries from 2020-11-18