1JWT
CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR
Summary for 1JWT
Entry DOI | 10.2210/pdb1jwt/pdb |
Descriptor | Prothrombin, 4-OXO-2-PHENYLMETHANESULFONYL-OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE-6-CARBOXYLIC ACID [1-(N-HYDROXYCARBAMIMIDOYL)-PIPERIDIN-4-YLMETHYL]-AMIDE (2 entities in total) |
Functional Keywords | hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00734 |
Total number of polymer chains | 1 |
Total formula weight | 35616.63 |
Authors | Levesque, S.,St-Denis, Y.,Bachand, B.,Preville, P.,Leblond, L.,Winocour, P.D.,Edmunds, J.J.,Rubin, J.R.,Siddiqui, M.A. (deposition date: 2001-09-05, release date: 2002-02-27, Last modification date: 2017-10-04) |
Primary citation | Levesque, S.,St-Denis, Y.,Bachand, B.,Preville, P.,Leblond, L.,Winocour, P.D.,Edmunds, J.J.,Rubin, J.R.,Siddiqui, M.A. Novel bicyclic lactam inhibitors of thrombin: potency and selectivity optimization through P1 residues. Bioorg.Med.Chem.Lett., 11:3161-3164, 2001 Cited by PubMed: 11720865DOI: 10.1016/S0960-894X(01)00661-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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