1JWT
CRYSTAL STRUCTURE OF THROMBIN IN COMPLEX WITH A NOVEL BICYCLIC LACTAM INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Prothrombin | polymer | 305 | 35124.0 | 1 | UniProt (P00734) Pfam (PF09396) Pfam (PF00089) | Homo sapiens (human) | COAGULATION FACTOR II |
| 2 | B (A) | 4-OXO-2-PHENYLMETHANESULFONYL-OCTAHYDRO-PYRROLO[1,2-A]PYRAZINE-6-CARBOXYLIC ACID [1-(N-HYDROXYCARBAMIMIDOYL)-PIPERIDIN-4-YLMETHYL]-AMIDE | non-polymer | 492.6 | 1 | Chemie (BLI) |
Sequence modifications
A: 1 - 289 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Asp 290 | - | cloning artifact |
| Phe 291 | - | cloning artifact |
| Glu 292 | - | cloning artifact |
| Glu 293 | - | cloning artifact |
| Ile 294 | - | cloning artifact |
| Pro 295 | - | cloning artifact |
| Glu 296 | - | cloning artifact |
| Glu 297 | - | cloning artifact |
| Tyr 298 | - | cloning artifact |
| Leu 299 | - | cloning artifact |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35124.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 492.6 | |
| All* | Total formula weight | 35616.6 |
