1NM6
thrombin in complex with selective macrocyclic inhibitor at 1.8A
Summary for 1NM6
Entry DOI | 10.2210/pdb1nm6/pdb |
Related | 1NT1 |
Descriptor | thrombin, Hirudin, (11S)-11-BENZYL-6-CHLORO-1,2,10,11,12,13,14,15,16,17,18,19-DODECAHYDRO-5,9-METHANO-2,5,8,10,13,17-BENZOHEXAAZACYCLOHENICOSINE-3,24-DIONE, ... (4 entities in total) |
Functional Keywords | thrombin inhibitor complex, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted, extracellular space: P00734 Secreted: P28504 |
Total number of polymer chains | 2 |
Total formula weight | 35023.48 |
Authors | Nantermet, P.G.,Barrow, J.C.,Newton, C.L.,Pellicore, J.M.,Young, M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,McMasters, D.R.,Yan, Y.,Kuo, L.C.,Vacca, J.P.,Selnick, H.G. (deposition date: 2003-01-09, release date: 2003-09-02, Last modification date: 2017-10-11) |
Primary citation | Nantermet, P.G.,Barrow, J.C.,Newton, C.L.,Pellicore, J.M.,Young, M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,McMasters, D.R.,Yan, Y.,Kuo, L.C.,Vacca, J.P.,Selnick, H.G. Design and synthesis of potent and selective macrocyclic thrombin inhibitors Bioorg.Med.Chem.Lett., 13:2781-2784, 2003 Cited by PubMed: 12873514DOI: 10.1016/S0960-894X(03)00506-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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