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8QZZ
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BU of 8qzz by Molmil
Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452
Descriptor: Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Yan, Y, Ron, D.
Deposit date:2023-10-30
Release date:2024-03-20
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Substrate recruitment via eIF2 gamma enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.
Proc.Natl.Acad.Sci.USA, 121, 2024
5MLG
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BU of 5mlg by Molmil
Crystal structure of rat prorenin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin
Authors:Yan, Y, Read, R.
Deposit date:2016-12-06
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of rat prorenin
To Be Published
5MKT
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BU of 5mkt by Molmil
Crystal structure of mouse prorenin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin-1
Authors:Yan, Y, Read, R.
Deposit date:2016-12-05
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of mouse prorenin
To Be Published
7NXV
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BU of 7nxv by Molmil
Crystal structure of the complex of DNase I/G-actin/PPP1R15A_582-621
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Yan, Y, Ron, D.
Deposit date:2021-03-19
Release date:2021-09-29
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
7NZM
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BU of 7nzm by Molmil
Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ...
Authors:Yan, Y, Hardwick, S, Ron, D.
Deposit date:2021-03-24
Release date:2021-09-29
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (3.96 Å)
Cite:Higher-order phosphatase-substrate contacts terminate the integrated stress response.
Nat.Struct.Mol.Biol., 28, 2021
6HA7
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BU of 6ha7 by Molmil
Crystal structure of the BiP NBD and MANF complex
Descriptor: 1,2-ETHANEDIOL, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor
Authors:Yan, Y, Ron, D.
Deposit date:2018-08-07
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.
Nat Commun, 10, 2019
6H9U
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BU of 6h9u by Molmil
Crystal structure of the BiP NBD and MANF SAP complex
Descriptor: D-MALATE, Endoplasmic reticulum chaperone BiP, Mesencephalic astrocyte-derived neurotrophic factor, ...
Authors:Yan, Y, Ron, D.
Deposit date:2018-08-06
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.
Nat Commun, 10, 2019
6HAB
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BU of 6hab by Molmil
Crystal structure of BiP V461F (apo)
Descriptor: DI(HYDROXYETHYL)ETHER, Endoplasmic reticulum chaperone BiP
Authors:Yan, Y, Ron, D.
Deposit date:2018-08-07
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:MANF antagonizes nucleotide exchange by the endoplasmic reticulum chaperone BiP.
Nat Commun, 10, 2019
2SPC
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BU of 2spc by Molmil
CRYSTAL STRUCTURE OF THE REPETITIVE SEGMENTS OF SPECTRIN
Descriptor: SPECTRIN
Authors:Yan, Y, Winograd, E, Viel, A, Cronin, T, Harrison, S.C, Branton, D.
Deposit date:1994-03-01
Release date:1994-05-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the repetitive segments of spectrin.
Science, 262, 1993
1NS3
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BU of 1ns3 by Molmil
STRUCTURE OF HCV PROTEASE (BK STRAIN)
Descriptor: NS3 PROTEASE, NS4A PEPTIDE, ZINC ION
Authors:Yan, Y, Munshi, S, Chen, Z.
Deposit date:1997-04-05
Release date:1998-04-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.
Protein Sci., 7, 1998
1JXP
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BU of 1jxp by Molmil
BK STRAIN HEPATITIS C VIRUS (HCV) NS3-NS4A
Descriptor: NS3 SERINE PROTEASE, NS4A, ZINC ION
Authors:Yan, Y, Munshi, S, Chen, Z.
Deposit date:1997-08-21
Release date:1998-01-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.
Protein Sci., 7, 1998
6I3I
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BU of 6i3i by Molmil
Crystal structure of reactive center loop (RCL) cleaved angiotensinogen
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen
Authors:Yan, Y, Read, R.J.
Deposit date:2018-11-06
Release date:2018-12-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
J. Biol. Chem., 294, 2019
6I3F
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BU of 6i3f by Molmil
Crystal structure of the complex of human angiotensinogen and renin at 2.55 Angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensinogen, ...
Authors:Yan, Y, Read, R.J.
Deposit date:2018-11-06
Release date:2018-12-26
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
J. Biol. Chem., 294, 2019
6C9H
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BU of 6c9h by Molmil
non-phosphorylated AMP-activated protein kinase bound to pharmacological activator R734
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9J
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BU of 6c9j by Molmil
AMP-activated protein kinase bound to pharmacological activator R734
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Brunzelle, J.S, Hitoshi, Y, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
6C9G
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BU of 6c9g by Molmil
AMP-activated protein kinase bound to pharmacological activator R739
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
5M3Y
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BU of 5m3y by Molmil
Crystal structure of human glycosylated angiotensinogen
Descriptor: Angiotensinogen, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Yan, Y, Read, R.J.
Deposit date:2016-10-17
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
J. Biol. Chem., 294, 2019
6C9F
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BU of 6c9f by Molmil
AMP-activated protein kinase bound to pharmacological activator R734
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Zhou, X.E, Novick, S, Shaw, S.J, Li, Y, Hitoshi, Y, Brunzelle, J.S, Griffin, P.R, Xu, H.E, Melcher, K.
Deposit date:2018-01-26
Release date:2018-11-28
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.924 Å)
Cite:Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states.
J. Biol. Chem., 294, 2019
5M3X
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BU of 5m3x by Molmil
Crystal structure of human angiotensin I-deleted angiotensinogen
Descriptor: Angiotensinogen
Authors:Yan, Y, Read, R.J.
Deposit date:2016-10-17
Release date:2017-12-20
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structural basis for the specificity of renin-mediated angiotensinogen cleavage.
J. Biol. Chem., 294, 2019
1MJA
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BU of 1mja by Molmil
Crystal structure of yeast Esa1 histone acetyltransferase domain complexed with acetyl coenzyme A
Descriptor: COENZYME A, Esa1 protein
Authors:Yan, Y, Harper, S, Speicher, D, Marmorstein, R.
Deposit date:2002-08-27
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat.Struct.Biol., 9, 2002
1MJ9
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BU of 1mj9 by Molmil
Crystal structure of yeast Esa1(C304S) mutant complexed with Coenzyme A
Descriptor: COENZYME A, ESA1 PROTEIN, SODIUM ION
Authors:Yan, Y, Harper, S, Speicher, D, Marmorstein, R.
Deposit date:2002-08-27
Release date:2002-10-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat.Struct.Biol., 9, 2002
1MJB
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BU of 1mjb by Molmil
Crystal structure of yeast Esa1 histone acetyltransferase E338Q mutant complexed with acetyl coenzyme A
Descriptor: ACETYL COENZYME *A, Esa1 protein
Authors:Yan, Y, Harper, S, Speicher, D, Marmorstein, R.
Deposit date:2002-08-27
Release date:2002-10-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The catalytic mechanism of the ESA1 histone acetyltransferase involves a self-acetylated intermediate.
Nat.Struct.Biol., 9, 2002
1Q0B
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BU of 1q0b by Molmil
Crystal structure of the motor protein KSP in complex with ADP and monastrol
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ETHYL 4-(3-HYDROXYPHENYL)-6-METHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-CARBOXYLATE, Kinesin-like protein KIF11, ...
Authors:Yan, Y, Sardana, V, Xu, B, Halczenko, W, Homnick, C, Buser, C.A, Hartman, G.D, Huber, H.E, Kuo, L.C.
Deposit date:2003-07-15
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of a mitotic motor protein: where, how, and conformational consequences
J.Mol.Biol., 335, 2004
7M74
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BU of 7m74 by Molmil
ATP-bound AMP-activated protein kinase
Descriptor: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
Authors:Yan, Y, Mukherjee, S, Harikumar, K.G, Strutzenberg, T, Zhou, X.E, Powell, S.K, Xu, T, Sheldon, R, Lamp, J, Brunzelle, J.S, Radziwon, K, Ellis, A, Novick, S.J, Vega, I.E, Jones, R, Miller, L.J, Xu, H.E, Griffin, P.R, Kossiakoff, A.A, Melcher, K.
Deposit date:2021-03-26
Release date:2021-12-15
Last modified:2021-12-22
Method:ELECTRON MICROSCOPY (3.93 Å)
Cite:Structure of an AMPK complex in an inactive, ATP-bound state.
Science, 373, 2021
5VZ6
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BU of 5vz6 by Molmil
HIV Reverse Transcriptase complexed with (E)-3-(pyrimidin-2-yl)-N-(5-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-3-yl)acrylamide
Descriptor: 3-(pyrimidin-2-yl)-N-[3-(5,6,7,8-tetrahydronaphthalen-2-yl)-1H-pyrazol-5-yl]propanamide, HIV Reverse Transcriptase
Authors:Yan, Y, Su, H.P.
Deposit date:2017-05-26
Release date:2018-05-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:HIV Reverse Transcriptase complexed with inhibitor
To Be Published

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PDB entries from 2024-09-18

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