7NZM
Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I)
Summary for 7NZM
| Entry DOI | 10.2210/pdb7nzm/pdb |
| EMDB information | 12665 |
| Descriptor | Eukaryotic translation initiation factor 2 subunit 1, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, Actin, alpha skeletal muscle, intermediate form, ... (8 entities in total) |
| Functional Keywords | holophosphatase, pp1, ppp1r15a, phosphorylated eif2alpha, hydrolase |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 5 |
| Total formula weight | 176576.99 |
| Authors | Yan, Y.,Hardwick, S.,Ron, D. (deposition date: 2021-03-24, release date: 2021-09-29, Last modification date: 2021-10-20) |
| Primary citation | Yan, Y.,Harding, H.P.,Ron, D. Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28:835-846, 2021 Cited by PubMed: 34625748DOI: 10.1038/s41594-021-00666-7 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.96 Å) |
Structure validation
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