8QZZ

Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452

Summary for 8QZZ

• Entry DOI: 10.2210/pdb8qzz/pdb
• Descriptor: Eukaryotic translation initiation factor 2 subunit 3, Eukaryotic translation initiation factor 2 subunit 1, Protein phosphatase 1 regulatory subunit 15A, ... (4 entities in total)
• Functional Keywords: eukaryotic initiation factor-2, pp1 regulatory subunit, dephosphorylation, metabolism, translation
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 91549.53

Authors

Yan, Y.,Ron, D. (deposition date: 2023-10-30, release date: 2024-03-20, Last modification date: 2024-04-10)

• Primary citation: Yan, Y.,Shetty, M.,Harding, H.P.,George, G.,Zyryanova, A.,Labbe, K.,Mafi, A.,Hao, Q.,Sidrauski, C.,Ron, D.; Substrate recruitment via eIF2 gamma enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.; Proc.Natl.Acad.Sci.USA, 121:e2320013121-e2320013121, 2024; PubMed: 38547060; DOI: 10.1073/pnas.2320013121

Experimental method

X-RAY DIFFRACTION (3.35 Å)