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8QZZ

Crystal structure of human eIF2 alpha-gamma complexed with PPP1R15A_420-452

Functional Information from GO Data
ChainGOidnamespacecontents
A0000049molecular_functiontRNA binding
A0001731biological_processformation of translation preinitiation complex
A0002183biological_processcytoplasmic translational initiation
A0003743molecular_functiontranslation initiation factor activity
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005850cellular_componenteukaryotic translation initiation factor 2 complex
A0006412biological_processtranslation
A0006413biological_processtranslational initiation
A0008135molecular_functiontranslation factor activity, RNA binding
A0016787molecular_functionhydrolase activity
A0045296molecular_functioncadherin binding
A0070062cellular_componentextracellular exosome
A1990856molecular_functionmethionyl-initiator methionine tRNA binding
B0000423biological_processmitophagy
B0003723molecular_functionRNA binding
B0003743molecular_functiontranslation initiation factor activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0005850cellular_componenteukaryotic translation initiation factor 2 complex
B0006412biological_processtranslation
B0006413biological_processtranslational initiation
B0006417biological_processregulation of translation
B0010494cellular_componentcytoplasmic stress granule
B0016020cellular_componentmembrane
B0032057biological_processnegative regulation of translational initiation in response to stress
B0033290cellular_componenteukaryotic 48S preinitiation complex
B0034063biological_processstress granule assembly
B0034198biological_processcellular response to amino acid starvation
B0034599biological_processcellular response to oxidative stress
B0034605biological_processcellular response to heat
B0034644biological_processcellular response to UV
B0034976biological_processresponse to endoplasmic reticulum stress
B0036490biological_processregulation of translation in response to endoplasmic reticulum stress
B0036499biological_processPERK-mediated unfolded protein response
B0043022molecular_functionribosome binding
B0043558biological_processregulation of translational initiation in response to stress
B0044207cellular_componenttranslation initiation ternary complex
B0045202cellular_componentsynapse
B0070062cellular_componentextracellular exosome
B0097451cellular_componentglial limiting end-foot
B0140468biological_processHRI-mediated signaling
B1904373biological_processresponse to kainic acid
B1990737biological_processresponse to manganese-induced endoplasmic reticulum stress
B2000676biological_processpositive regulation of type B pancreatic cell apoptotic process
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0000269|PubMed:24092754
ChainResidueDetails
CTYR434
AASN190
ASER225

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER52

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS141

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BSER158

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTHR279
BTHR281

219869

PDB entries from 2024-05-15

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