6C9F

AMP-activated protein kinase bound to pharmacological activator R734

Summary for 6C9F

Entry DOI	10.2210/pdb6c9f/pdb
Descriptor	5'-AMP-activated protein kinase catalytic subunit alpha-1,5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ... (6 entities in total)
Functional Keywords	ampk, activator, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	3
Total formula weight	119898.31
Authors	Yan, Y.,Zhou, X.E.,Novick, S.,Shaw, S.J.,Li, Y.,Hitoshi, Y.,Brunzelle, J.S.,Griffin, P.R.,Xu, H.E.,Melcher, K. (deposition date: 2018-01-26, release date: 2018-11-28, Last modification date: 2019-12-25)
Primary citation	Yan, Y.,Zhou, X.E.,Novick, S.J.,Shaw, S.J.,Li, Y.,Brunzelle, J.S.,Hitoshi, Y.,Griffin, P.R.,Xu, H.E.,Melcher, K. Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states. J. Biol. Chem., 294:953-967, 2019 Cited by PubMed: 30478170 DOI: 10.1074/jbc.RA118.004883 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.924 Å)

Structure validation