1NS3

STRUCTURE OF HCV PROTEASE (BK STRAIN)

Summary for 1NS3

• Entry DOI: 10.2210/pdb1ns3/pdb
• Descriptor: NS3 PROTEASE, NS4A PEPTIDE, ZINC ION, ... (4 entities in total)
• Functional Keywords: hydrolase, serine proteinase, complex (hydrolase-peptide), complex (hydrolase-peptide) complex, complex (hydrolase/peptide)
• Biological source: Hepatitis C virus; More
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663 P26663
• Total number of polymer chains: 4
• Total formula weight: 42672.21

Authors

Yan, Y.,Munshi, S.,Chen, Z. (deposition date: 1997-04-05, release date: 1998-04-08, Last modification date: 2024-02-14)

• Primary citation: Yan, Y.,Li, Y.,Munshi, S.,Sardana, V.,Cole, J.L.,Sardana, M.,Steinkuehler, C.,Tomei, L.,De Francesco, R.,Kuo, L.C.,Chen, Z.; Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: a 2.2 A resolution structure in a hexagonal crystal form.; Protein Sci., 7:837-847, 1998; PubMed: 9568891

Experimental method

X-RAY DIFFRACTION (2.8 Å)