1NS3

STRUCTURE OF HCV PROTEASE (BK STRAIN)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NS3 PROTEASE	polymer	186	19798.8	2	UniProt (P26663) Pfam (PF02907)	Hepatitis C virus
2	C, D (C, D)	NS4A PEPTIDE	polymer	14	1471.9	2	UniProt (P26663)	Hepatitis C virus
3	E, F (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	G, H (A, B)	water	water		18.0	2	Chemie (HOH)

Sequence modifications

A, B: 2 - 180 (UniProt: P26663)

PDB	External Database	Details
-	Pro 1028	deletion
Gly 66	Ala 1092	conflict
Gln 86	Pro 1112	conflict
Ala 87	Lys 1113	conflict
Ser 147	Phe 1173	conflict

C, D: 221 - 233 (UniProt: P26663)

PDB	External Database	Details
-	Gly 1690	deletion

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	42541.4
Non-Polymers*	Number of molecules	2
	Total formula weight	130.8
All*	Total formula weight	42672.2

*Water molecules are not included.