1NS3

STRUCTURE OF HCV PROTEASE (BK STRAIN)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	symbiont-mediated transformation of host cell
B	0006508	biological_process	proteolysis
B	0008236	molecular_function	serine-type peptidase activity
B	0019087	biological_process	symbiont-mediated transformation of host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 190

Chain	Residue
A	CYS97
A	THR98
A	CYS99
A	CYS145
A	HIS149

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 690

Chain	Residue
B	CYS97
B	CYS99
B	CYS145
B	SER147

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:8861916

Chain	Residue	Details
A	HIS57
A	ASP81
B	HIS57
B	ASP81

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site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Charge relay system; for serine protease NS3 activity => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:8861916, ECO:0000269|PubMed:9568891

Chain	Residue	Details
A	SER139
B	SER139

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:10366511, ECO:0000269|PubMed:8861916, ECO:0000269|PubMed:9568891

Chain	Residue	Details
A	CYS97
A	CYS99
B	CYS97
B	CYS99

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01166, ECO:0000269|PubMed:10366511, ECO:0000269|PubMed:8861916

Chain	Residue	Details
A	CYS145
A	HIS149
B	CYS145
B	HIS149

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
A	ASP81
A	SER139
A	GLY137
A	HIS57

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site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1rgq

Chain	Residue	Details
B	ASP81
B	SER139
B	GLY137
B	HIS57

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