1NM6
thrombin in complex with selective macrocyclic inhibitor at 1.8A
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | thrombin | polymer | 287 | 33080.0 | 1 | UniProt (P00734) Pfam (PF09396) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (B) | Hirudin | polymer | 11 | 1434.5 | 1 | UniProt (P28504) | ||
| 3 | C (A) | (11S)-11-BENZYL-6-CHLORO-1,2,10,11,12,13,14,15,16,17,18,19-DODECAHYDRO-5,9-METHANO-2,5,8,10,13,17-BENZOHEXAAZACYCLOHENI COSINE-3,24-DIONE | non-polymer | 509.0 | 1 | Chemie (L86) PubChem (4369278) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
B: 355 - 365 (UniProt: P28504)
| PDB | External Database | Details |
|---|---|---|
| Ala 365 | Gln 65 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 34514.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 509.0 | |
| All* | Total formula weight | 35023.5 |
