1OYT
COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR
Summary for 1OYT
Entry DOI | 10.2210/pdb1oyt/pdb |
Related PRD ID | PRD_000481 |
Descriptor | thrombin light chain, thrombin heavy chain, Hirudin IIB, ... (7 entities in total) |
Functional Keywords | serine proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 Secreted: P28506 |
Total number of polymer chains | 3 |
Total formula weight | 35743.73 |
Authors | Banner, D.W.,Olsen, J.A. (deposition date: 2003-04-07, release date: 2003-06-24, Last modification date: 2024-04-03) |
Primary citation | Olsen, J.A.,Banner, D.W.,Seiler, P.,Obst-Sander, U.,D'Arcy, A.,Stihle, M.,Mueller, K.,Diederich, F. A Fluorine Scan of Thrombin Inhibitors to Map the Fluorophilicity/Fluorophobicity of an Enzyme Active Site: Evidence for CF...C=O Interactions. Angew.Chem.Int.Ed.Engl., 42:2507-2511, 2003 Cited by PubMed: 12800172DOI: 10.1002/anie.200351268 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.67 Å) |
Structure validation
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