1OYT
COMPLEX OF RECOMBINANT HUMAN THROMBIN WITH A DESIGNED FLUORINATED INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (L) | thrombin light chain | polymer | 36 | 4096.5 | 1 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II |
| 2 | B (H) | thrombin heavy chain | polymer | 259 | 29780.2 | 1 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II |
| 3 | C (I) | Hirudin IIB | polymer | 11 | 1396.5 | 1 | UniProt (P28506) BIRD (PRD_000481) | Hirudo medicinalis | |
| 4 | D (H) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | E (H) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 6 | F (H) | (3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE | non-polymer | 407.5 | 1 | Chemie (FSN) | |||
| 7 | G, H, I (L, H, I) | water | water | 18.0 | 404 | Chemie (HOH) |
Sequence modifications
I: 1 - 11 (UniProt: P28506)
| PDB | External Database | Details |
|---|---|---|
| Sin 1 | Asp 55 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 35273.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 470.5 | |
| All* | Total formula weight | 35743.7 |
