1NY2

Human alpha thrombin inhibited by RPPGF and hirugen

Summary for 1NY2

Entry DOI	10.2210/pdb1ny2/pdb
Related	1HDT 1TMU 7KME 8KME
Descriptor	thrombin light chain, thrombin Heavy chain, Hirugen, ... (5 entities in total)
Functional Keywords	thrombosis, retro binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734 Secreted: P28504
Total number of polymer chains	4
Total formula weight	35813.82
Authors	Krishnan, R.,Tulinsky, A.,Schmaier, A.H.,Hasan, A.A.,Warnock, M.,Srikanth, S.,Mahdi, F. (deposition date: 2003-02-11, release date: 2003-03-04, Last modification date: 2023-11-15)
Primary citation	Hasan, A.A.,Warnock, M.,Nieman, M.,Srikanth, S.,Mahdi, F.,Krishnan, R.,Tulinsky, A.,Schmaier, A.H. Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin. Am.J.Physiol.Heart Circ.Physiol., 285:H183-H193, 2003 Cited by PubMed: 12598231 DOI: 10.1152/ajpheart.00490.2002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation