1NY2

Human alpha thrombin inhibited by RPPGF and hirugen

Summary for 1NY2
Related1HDT 1TMU 7KME 8KME
Descriptorthrombin light chain, thrombin Heavy chain, Hirugen, ... (5 entities in total)
Functional Keywordsthrombosis, retro binding, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Secreted: P28504
Total number of polymer chains4
Total formula weight35813.82
Authors
Krishnan, R.,Tulinsky, A.,Schmaier, A.H.,Hasan, A.A.,Warnock, M.,Srikanth, S.,Mahdi, F. (deposition date: 2003-02-11, release date: 2003-03-04, Last modification date: 2017-10-11)
Primary citationHasan, A.A.,Krishnan, R.,Mahdi, F.,Nieman, M.,Schmaier, A.H.,Srikanth, S.,Tulinsky, A.,Warnock, M.
Mechanisms of Arg-Pro-Pro-Gly-Phe inhibition of thrombin.
Am.J.Physiol.Heart Circ.Physiol., 285:H183-H193, 2003
PubMed: 12598231
DOI: 110.1152/ajpheart.00490.2002
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation
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179210

PDB entries from 2021-06-23