1NY2

Human alpha thrombin inhibited by RPPGF and hirugen

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0004252	molecular_function	serine-type endopeptidase activity
1	0005576	cellular_component	extracellular region
1	0006508	biological_process	proteolysis
1	0007596	biological_process	blood coagulation
2	0004252	molecular_function	serine-type endopeptidase activity
2	0005509	molecular_function	calcium ion binding
2	0006508	biological_process	proteolysis
2	0007596	biological_process	blood coagulation

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	BINDING SITE FOR CHAIN 3 OF HIRUGEN

Chain	Residue
2	PHE34
2	ASN98
2	ASP100
2	ARG175
3	HOH423
3	HOH429
2	LYS36
2	LEU65
2	ARG67
2	ARG73
2	THR74
2	TYR76
2	ILE82
2	GLU97

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
2	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAceGDSGGPFV

Chain	Residue	Details
2	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: 4-hydroxyproline; partial => ECO:0000269|PubMed:3182782, ECO:0000269|PubMed:3366244

Chain	Residue	Details
4	PRO382
2	ASP102
2	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:873923

Chain	Residue	Details
2	ASN60

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