1HBT
Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor
Summary for 1HBT
Entry DOI | 10.2210/pdb1hbt/pdb |
Descriptor | ALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), P596 Inhibitor peptide, ... (4 entities in total) |
Functional Keywords | serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted, extracellular space: P00734 P00734 |
Total number of polymer chains | 3 |
Total formula weight | 35993.08 |
Authors | Rehse, P.H.,Cygler, M. (deposition date: 1995-04-06, release date: 1995-07-10, Last modification date: 2023-11-15) |
Primary citation | Rehse, P.H.,Steinmetzer, T.,Li, Y.,Konishi, Y.,Cygler, M. Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin. Biochemistry, 34:11537-11544, 1995 Cited by PubMed: 7547884DOI: 10.1021/bi00036a029 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report