1HBT

Human alpha-thrombin complexed with a peptidyl pyridinium methyl ketone containing bivalent inhibitor

Summary for 1HBT
DescriptorALPHA-THROMBIN (SMALL SUBUNIT), ALPHA-THROMBIN (LARGE SUBUNIT), P596 Inhibitor peptide, ... (4 entities in total)
Functional Keywordsserine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
More
Cellular locationSecreted, extracellular space: P00734 P00734
Total number of polymer chains3
Total formula weight35993.08
Authors
Rehse, P.H.,Cygler, M. (deposition date: 1995-04-06, release date: 1995-07-10, Last modification date: 2011-07-13)
Primary citationCygler, M.,Konishi, Y.,Li, Y.,Rehse, P.H.,Steinmetzer, T.
Crystal structure of a peptidyl pyridinium methyl ketone inhibitor with thrombin.
Biochemistry, 34:11537-11544, 1995
PubMed: 7547884
DOI: 110.1021/bi00036a029
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation
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PDB entries from 2021-06-23