1QBV

CRYSTAL STRUCTURE OF THROMBIN COMPLEXED WITH AN GUANIDINE-MIMETIC INHIBITOR

Summary for 1QBV

• Entry DOI: 10.2210/pdb1qbv/pdb
• Descriptor: THROMBIN (LIGHT CHAIN), THROMBIN (HEAVY CHAIN), Hirudin, ... (5 entities in total)
• Functional Keywords: thrombin, inhibitor, 3dp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• Total number of polymer chains: 3
• Total formula weight: 35749.75

Authors

Bone, R.,Lu, T.,Illig, C.R.,Soll, R.M.,Spurlino, J.C. (deposition date: 1999-04-27, release date: 1999-10-27, Last modification date: 2017-10-04)

• Primary citation: Bone, R.,Lu, T.,Illig, C.R.,Soll, R.M.,Spurlino, J.C.; Structural analysis of thrombin complexed with potent inhibitors incorporating a phenyl group as a peptide mimetic and aminopyridines as guanidine substitutes.; J.Med.Chem., 41:2068-2075, 1998; PubMed: 9622548; DOI: 10.1021/jm970796l

Experimental method

X-RAY DIFFRACTION (1.8 Å)