Entry Database : PDB / ID : 2uuy Structure visualization Downloads & linksTitle Structure of a tick tryptase inhibitor in complex with bovine trypsin ComponentsCATIONIC TRYPSIN TRYPTASE INHIBITOR DetailsKeywords HYDROLASE / CALCIUM / ZYMOGEN / PROTEASE / DIGESTION / METAL-BINDING / SERINE PROTEASE / TRYPTASE INHIBITORFunction / homology Function and homology informationFunction Domain/homology Component
trypsin / serpin family protein binding / serine protease inhibitor complex / digestion / serine-type endopeptidase inhibitor activity / endopeptidase activity / serine-type endopeptidase activity / proteolysis / extracellular space / metal ion binding Similarity search - Function Pancreatic trypsin inhibitor Kunitz domain / Factor Xa Inhibitor / Pancreatic trypsin inhibitor Kunitz domain superfamily / : / Few Secondary Structures / Irregular / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. ... Pancreatic trypsin inhibitor Kunitz domain / Factor Xa Inhibitor / Pancreatic trypsin inhibitor Kunitz domain superfamily / : / Few Secondary Structures / Irregular / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin family, serine active site. / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species BOS TAURUS (cattle)RHIPICEPHALUS APPENDICULATUS (arthropod)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.15 Å DetailsAuthors Siebold, C. / Paesen, G.C. / Harlos, K. / Peacey, M.F. / Nuttall, P.A. / Stuart, D.I. CitationJournal : J.Mol.Biol. / Year : 2007Title : A Tick Protein with a Modified Kunitz Fold Inhibits Human Tryptase.Authors : Paesen, G.C. / Siebold, C. / Harlos, K. / Peacey, M.F. / Nuttall, P.A. / Stuart, D.I. History Deposition Mar 8, 2007 Deposition site : PDBE / Processing site : PDBERevision 1.0 Apr 10, 2007 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format compliance
Show all Show less Remark 700 SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW ... SHEET DETERMINATION METHOD: DSSP THE SHEETS PRESENTED AS "AB" IN EACH CHAIN ON SHEET RECORDS BELOW IS ACTUALLY AN 6-STRANDED BARREL THIS IS REPRESENTED BY A 7-STRANDED SHEET IN WHICH THE FIRST AND LAST STRANDS ARE IDENTICAL.