1H8D

X-ray structure of the human alpha-thrombin complex with a tripeptide phosphonate inhibitor.

Summary for 1H8D
Related1A2C 1A3B 1A3E 1A46 1A4W 1A5G 1A61 1ABI 1ABJ 1AD8 1AE8 1AFE 1AHT 1AI8 1AIX 1AWF 1AWH 1AY6 1B5G 1B7X 1BA8 1BB0 1BCU 1BHX 1BMM 1BMN 1BTH 1C1U 1C1V 1C1W 1C4U 1C4V 1C4Y 1C5L 1C5N 1C5O 1CA8 1D3D 1D3P 1D3Q 1D3T 1D4P 1D6W 1D9I 1DE7 1DIT 1DM4 1DWB 1DWC 1DWD 1DWE 1DX5 1E0F 1EOJ 1EOL 1FPC 1FPH 1HAG 1HAH 1HAI 1HAO 1HAP 1HBT 1HDT 1HGT 1HLT 1HUT 1HXE 1HXF 1IHS 1IHT 1LHC 1LHD 1LHE 1LHF 1LHG 1NRN 1NRO 1NRP 1NRQ 1NRR 1NRS 1PPB 1QBV 1QHR 1QJ1 1QJ6 1QJ7 1QUR 1TBZ 1THP 1THR 1THS 1TMB 1TMT 1TMU 1TOM 1UMA 1UVS 1VR1 2HGT 2HNT 2HPP 2HPQ 2THF 3HAT 3HTC 4HTC 4THN 5GDS 7KME 8KME
DescriptorTHROMBIN, HIRUDIN I, N-[(benzyloxy)carbonyl]-beta-phenyl-D-phenylalanyl-N-{(1S,3E)-1-[dihydroxy(diphenoxy)-lambda~5~-phosphanyl]-4-methoxybut-3-en-1-yl}-L-prolinamide, ... (5 entities in total)
Functional Keywordsserine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHOMO SAPIENS (HUMAN)
More
Total number of polymer chains3
Total formula weight35371.46
Authors
Skordalakes, E.,Dodson, G.G.,Green, D.,Deadman, J. (deposition date: 2001-02-01, release date: 2001-02-26, Last modification date: 2018-11-21)
Primary citationDeadman, J.J.,Dodson, G.G.,Goodwin, C.A.,Green, D.S.,Hudson, H.R.,Kakkar, V.V.,Scully, M.F.,Skordalakes, E.
Inhibition of Human Alpha-Thrombin by a Phosphonate Tripeptide Proceeds Via a Metastable Pentacoordinated Phosphorus Intermediate
J.Mol.Biol., 311:549-, 2001
PubMed: 11493008
DOI: 110.1006/JMBI.2001.4872
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB Foundation
wwPDBRCSB PDBPDBeBMRBAdv. SearchSearch help

178938

PDB entries from 2021-06-16