2XTT

Bovine trypsin in complex with evolutionary enhanced Schistocerca gregaria protease inhibitor 1 (SGPI-1-P02)

Summary for 2XTT

Related5PTP 1O2S 1O2T 1BJV 1C2D 1C2E 1MTS 1TPS 1KJ0 1TNG 1O2M 1C1P 1JRT 2BTC 1C1T 1TNK 1O2X 1D6R 1O38 1C2H 1UTP 1GI1 1F2S 1TIO 1V2K 1TPO 2BLW 1V2O 2FX6 1C1N 1Y3U 1Y3X 1C5P 1O2I 1C2J 1N6X 1C5U 1O3M 1K1O 1V2V 1GHZ 1Y5U 2FI3 1QB1 2PTC 1K1L 2TGD 1Y5B 1C5T 1P2J 1SMF 1BTP 2AYW 1KIO 1PPE 1BTX 2BY8 1GI6 1CU8 1C5Q 1NTP 1QB9 1G3E 1O35 3BTK 1EJM 3PTN 1UTO 1O3H 2FI4 1Y3Y 1O2K 1O3I 1PPC 1O3D 1O2Y 1J8A 1C1Q 1O2L 1Y59 2TGT 3BTM 1V2S 1O2O 1XUI 1QL8 3BTF 1S0Q 1O2W 1BJU 1QB6 1GI5 1O39 1TAB 1GI2 1G3D 1CU7 1TPA 1O2H 2FTL 1MTV 1V2R 1O3L 1O2R 1TX8 3BTH 1V2J 1O3C 1C2I 1O3K 1EZX 1K1M 1CE5 1UTN 2BY7 1O32 1K1I 1YP9 1MAX 1TGC 1OPH 3BTE 1V2N 2TIO 3TPI 1EB2 2TLD 1BTY 2PTN 2FI5 1V2T 2TGA 1C2L 1O2V 1O36 2CMY 1F0U 2BY6 1TGT 1O33 1C2F 3BTQ 1AZ8 1TGB 1O3E 1QCP 3BTT 1O3O 1P2I 1TX7 1C2M 1O30 1Y5A 1S0R 1O2Z 1SBW 1AQ7 1QBO 1OYQ 1BTW 1XUJ 1V2Q 1UTQ 1MTU 1TGN 1K1P 1K1J 1GI3 1TPP 1O2Q 1O3A 1C9T 1HJ9 1G9I 1GI4 2FTM 1OX1 1V2W 2BLV 1QL7 1G3B 1MTW 1TLD 1QA0 1LQE 1TNH 1O3F 1XUG 1O3B 1O3J 1RXP 1C1R 1TNI 1BTZ 1Y3V 3BTW 1V2M 1NC6 1O2U 1YYY 1C2G 1C1S 3BTD 1TAW 1ZZZ 2TGP 1JRS 1TNL 2FX4 1C1O 1F0T 1N6Y 1K1N 1ZR0 1V2U 1JIR 1KGM 1MAY 2BY5 2AH4 1XUK 1GI0 2UUY 1TYN 1TGS 1O31 1V2P 2A7H 2TPI 1O37 1QBN 2BYA 1V2L 1O2J 4TPI 1SFI 1P2K 1O34 1XUH 2BZA 1G36 1C5V 1G3C 1GBT 3BTG 1PPH 1CU9 1O3N 3PTB 1O3G 1C5R 1XUF 1C5S 1TNJ 2BY9 1O2N 1C2K 1GJ6 1Y3W 1AUJ 1O2P 2J9N
DescriptorPROTEASE INHIBITOR SGPI-1, CATIONIC TRYPSIN, CALCIUM ION, ... (5 entities in total)
Functional Keywordshydrolase, catalytic mechanism, inhibition, in vitro evolution
Biological sourceBOS TAURUS (BOVINE)
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Cellular locationSecreted O46162
Secreted, extracellular space P00760
Total number of polymer chains2
Total molecular weight27355.81
Authors
Wahlgren, W.Y.,Pal, G.,Kardos, J.,Porrogi, P.,Szenthe, B.,Patthy, A.,Graf, L.,Katona, G. (deposition date: 2010-10-12, release date: 2010-11-10, Last modification date: 2017-07-12)
Primary citation
Wahlgren, W.Y.,Pal, G.,Kardos, J.,Porrogi, P.,Szenthe, B.,Patthy, A.,Graf, L.,Katona, G.
The Catalytic Aspartate is Protonated in the Michaelis Complex Formed between Trypsin and an in Vitro Evolved Substrate-Like Inhibitor: A Refined Mechanism of Serine Protease Action.
J.Biol.Chem., 286:3587-, 2011
PubMed: 21097875 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (0.93 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.130201.0%0.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2xtt
no rotation
Molmil generated image of 2xtt
rotated about x axis by 90°
Molmil generated image of 2xtt
rotated about y axis by 90°