1P2J

Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin

Summary for 1P2J
Related1P2I 1P2K 1P2M 1P2N 1P2O 1P2Q
DescriptorTrypsinogen, cationic, Pancreatic trypsin inhibitor, CALCIUM ION, ... (5 entities in total)
Functional Keywordstrypsin; chymotrypsin; serine proteinase; bovine pancreatic trypsin inhibitor; protein-protein interaction; non-cognate binding; s1 pocket; primary specificity; crystal structure, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceBos taurus (cattle)
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Cellular locationSecreted, extracellular space: P00760
Secreted: P00974
Total number of polymer chains2
Total formula weight30242.13
Authors
Helland, R.,Czapinska, H.,Leiros, I.,Olufsen, M.,Otlewski, J.,Smalaas, A.O. (deposition date: 2003-04-15, release date: 2004-04-20, Last modification date: 2011-07-13)
Primary citationCzapinska, H.,Helland, R.,Leiros, I.,Olufsen, M.,Otlewski, J.,Smalaas, A.O.
Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin.
J.Mol.Biol., 333:845-861, 2003
PubMed: 14568540
DOI: 110.1016/j.jmb.2003.08.059
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.35 Å)
Structure validation
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PDB entries from 2021-06-16