1P2J

Structural consequences of accommodation of four non-cognate amino-acid residues in the S1 pocket of bovine trypsin and chymotrypsin

Summary for 1P2J

Entry DOI	10.2210/pdb1p2j/pdb
Related	1P2I 1P2K 1P2M 1P2N 1P2O 1P2Q
Descriptor	Trypsinogen, cationic, Pancreatic trypsin inhibitor, CALCIUM ION, ... (5 entities in total)
Functional Keywords	trypsin; chymotrypsin; serine proteinase; bovine pancreatic trypsin inhibitor; protein-protein interaction; non-cognate binding; s1 pocket; primary specificity; crystal structure, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Bos taurus (cattle) More
Cellular location	Secreted, extracellular space: P00760 Secreted: P00974
Total number of polymer chains	2
Total formula weight	30242.13
Authors	Helland, R.,Czapinska, H.,Leiros, I.,Olufsen, M.,Otlewski, J.,Smalaas, A.O. (deposition date: 2003-04-15, release date: 2004-04-20, Last modification date: 2023-08-16)
Primary citation	Helland, R.,Czapinska, H.,Leiros, I.,Olufsen, M.,Otlewski, J.,Smalaas, A.O. Structural consequences of accommodation of four non-cognate amino acid residues in the S1 pocket of bovine trypsin and chymotrypsin. J.Mol.Biol., 333:845-861, 2003 Cited by PubMed: 14568540 DOI: 10.1016/j.jmb.2003.08.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.35 Å)

Structure validation